Tolvaptan API (CAS 150683-30-0) – GMP Bulk Supply
What is Tolvaptan API?
Tolvaptan (CAS 150683-30-0) is a benzazepine-derived, selective vasopressin V₂ receptor antagonist in the vaptan class. It is used in pharmaceutical manufacturing for hyponatremia and autosomal dominant polycystic kidney disease (ADPKD) therapies. Its aquaretic action helps remove excess water without significant electrolyte loss.
What are the main uses of Tolvaptan in pharmaceutical manufacturing?
- Formulation of hyponatremia treatment drugs for SIADH, heart failure, and cirrhosis.
- Development of ADPKD medications to slow kidney cyst growth and preserve renal function.
- R&D on aquaretic agents and vasopressin receptor modulators.
What are the synonyms and identifiers for Tolvaptan?
- OPC-41061
- DrugBank ID: DB06212
- IUPAC Name: 7-chloro-5-hydroxy-2-(1-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1-(2-methylbenzoyl)-1,2,3,4-tetrahydroisoquinoline-2,4-dione
What are the technical specifications of Tolvaptan API?
| Property | Specification |
| CAS Number | 150683-30-0 |
| Molecular Formula | C₂₆H₂₅ClN₂O₃ |
| Molecular Weight | 448.94 g/mol |
| Form | Off-white to light yellow powder |
| Purity | ≥99% (HPLC) |
| Mechanism | Selective V₂ receptor blockade in kidney collecting ducts, reducing aquaporin-2 insertion and free water reabsorption |
Why choose Pharmint for sourcing Tolvaptan API?
- GMP-certified production with consistent pharmaceutical-grade purity.
- Bulk supply readiness for manufacturing and formulation houses.
- Regulatory compliance with COA, MSDS, and stability data provided.
- Global export expertise including handling of regulated shipments.
How should Tolvaptan API be stored and handled?
- Keep in tightly sealed containers.
- Store in a cool, dry place away from light and moisture.
- Follow ICH guidelines for controlled storage conditions.
What are the regulatory and shipping requirements for Tolvaptan API?
- For laboratory and manufacturing use only — not for direct human or veterinary consumption without approved formulation.
- May require REMS compliance or equivalent for ADPKD drugs in certain markets.
- International shipments need end-use declaration and follow IATA/IMO rules.
Tolvaptan API FAQs
What is Tolvaptan API used for in drug manufacturing?
It is used in making formulations for hyponatremia and ADPKD, acting via selective vasopressin V₂ receptor antagonism.
Can Tolvaptan be purchased for research purposes?
Yes, GMP-grade Tolvaptan API is available for licensed R&D and formulation development with complete quality documentation.
Is Pharmint’s Tolvaptan API GMP certified?
Yes, our Tolvaptan API is produced in GMP-compliant facilities for regulatory-ready quality.
Does Tolvaptan API require special export documentation?
Yes, depending on the destination, an end-use declaration and regulatory clearance may be required.
How is Tolvaptan API packaged for global shipment?
Sealed containers with moisture/light protection, shipped under compliant temperature and safety conditions.
Reviews
There are no reviews yet.