Methasterone (Methyldrostanolone)
High-Potency Oral Anabolic Steroid for Research Use Only
What Is Methasterone?
Methasterone, also known as Superdrol or methyldrostanolone, is a synthetic oral anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). Originally synthesized by Syntex in 1956, it features 17α-alkylation and dimethyl substitution to enhance oral activity and anabolic strength.
Applications
- Anabolic efficacy studies in muscle mass development
- Hepatotoxicity profiling of 17α-alkylated steroids
- Urinary metabolite mapping for anti-doping laboratories
- Structure-activity relationship (SAR) comparison with methyltestosterone, oxymetholone
- Preclinical screening of androgenic receptor modulators
Technical Specifications
- CAS Number: 3381-88-2
- Chemical Name: 2α,17α-dimethyl-5α-androstan-17β-ol-3-one
- Molecular Formula: C21H34O2
- Molecular Weight: 318.50 g/mol
- Purity: ≥98% (HPLC)
- Appearance: White to off-white crystalline powder
- Synonyms: Methyldrostanolone, Superdrol
- MOQ & Package: 10g; Package according to demand
- Shipping: Safe and fast delivery
Mechanism of Action
Methasterone exerts potent anabolic effects via high-affinity binding to androgen receptors. It boasts approximately 400% the anabolic potency of methyltestosterone and only 20% of its androgenic activity, yielding a 20:1 anabolic-to-androgenic ratio. Its 17α-methylation enables oral bioavailability (~50%) but also contributes to hepatotoxic risk.
Research Considerations
Due to its hepatotoxic profile, Methasterone is suitable for in vitro or tightly controlled in vivo studies. It is valuable for understanding steroid-induced liver effects, metabolic pathways, and structural pharmacology of designer steroids.
Why Source from Pharmint?
- High-purity research-grade compound
- COA, MSDS, and batch analytics available
- B2B bulk supply with global shipping
- Regulatory-aware handling and documentation
- Secure end-use verification protocols
Storage & Stability
Store at –20°C in a sealed container. Avoid exposure to heat, moisture, and light. Stable for up to 24 months under recommended conditions.
Regulatory & Export Notes
- Intended Use: For research/laboratory use only
- Human/Veterinary Use: Prohibited
- Documentation: Requires signed end-use statement for export compliance
Methasterone FAQs
What is Methasterone used for in research?
Methasterone is primarily used to study anabolic receptor binding, liver toxicity mechanisms, and to analyze its metabolic derivatives for doping control.
How does Methasterone compare to methyltestosterone?
It has 400% higher anabolic activity but only 20% androgenic activity, showing greater muscle-building selectivity and increased liver impact.
Is Methasterone legally regulated?
Yes, it is listed as a Schedule III controlled substance in the U.S. and appears on WADA’s prohibited list. It is for lab research only.
Can Methasterone be used in animal studies?
Its use in animal models is permitted under controlled settings for metabolic and pharmacokinetic profiling, especially in hepatic toxicity research.
What are common metabolites of Methasterone?
Hydroxylated and TMS-derivatized metabolites (M1–M9) are found in urine, used for anti-doping detection and steroid profiling studies.
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