AC-262,536 (CAS 870888-46-3)
Tissue-Selective Non-Steroidal SARM for Research Use
What Is AC-262,536?
AC-262,536 is a potent, non-steroidal selective androgen receptor modulator (SARM) exhibiting strong anabolic activity and minimal androgenic effects. Originally developed by Acadia Pharmaceuticals, it serves as a research compound for understanding androgen receptor modulation and tissue selectivity without the liabilities of traditional steroidal agents.
Applications
- Preclinical evaluation of androgen receptor partial agonists
- Muscle wasting, osteoporosis, or sarcopenia model development
- Comparative studies with ACP-105, RAD140, Enobosarm
- Equine anti-doping and metabolic profiling
- HPG-axis suppression research in vivo models
Technical Specifications
- CAS Number: 870888-46-3
- Molecular Formula: C16H19FN2O
- Molecular Weight: 274.33 g/mol
- Purity: ≥98% (HPLC)
- Form: Off-white to yellow solid
- Structure: Aniline-substituted naphthalenyl isomer
- Synonyms: AC262, partial AR agonist
- MOQ & Package: 10g; Package according to demand
- Shipping: Safe and fast delivery
- Store & Shelf life: Cool & dry place; 24…
Mechanism & Selectivity
AC-262,536 binds to the androgen receptor (AR) with a high affinity (Ki ≈ 5 nM) and partial agonism (EC50 ≈ 1.6 nM). It induces hypertrophy in skeletal muscle tissue while sparing prostate growth, demonstrating a favorable anabolic:androgenic ratio. Unlike steroidal AR ligands, AC-262,536 shows no affinity for other nuclear receptors, enhancing its selectivity for pharmacological applications.
Why Choose Pharmint?
- Bulk availability for institutional R&D
- COA, MSDS, and full analytical documentation provided
- GMP-compliant partner labs and third-party testing
- Global sourcing logistics with end-use verification
- Discreet, regulation-aware B2B shipping
Storage & Stability
Store in a tightly sealed container at –20°C. Stable under recommended conditions for up to 24 months.
Regulatory & Shipping Information
- Intended Use: For laboratory research only
- Regulatory Note: Not for human or veterinary use
- Shipping: International delivery available with proper end-use declarations and import compliance
AC-262,536 FAQs
What is AC-262,536 used for in research?
AC-262,536 is used to study selective androgen receptor activation in muscle tissue and endocrine feedback systems without triggering significant androgenic side effects.
Is AC-262,536 a full agonist or partial agonist?
It functions as a partial agonist of the androgen receptor, which enables tissue-specific anabolic effects while minimizing undesired endocrine disruption.
Can AC-262,536 be used in animal studies?
Yes, it has been applied in rodent and equine models to assess tissue selectivity, hormone modulation, and metabolic fate, pending local research regulations.
How does AC-262,536 compare to RAD140 or ACP-105?
AC-262,536 offers similar anabolic effects but exhibits lower androgenic activity. Its molecular scaffold differs, offering value for comparative SAR studies.
Does AC-262,536 require special documentation for export?
Yes, an end-use declaration is mandatory for export due to potential regulatory restrictions in certain jurisdictions.
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