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DIPF is not commonly used as an API or drug substance itself but is often used as an intermediate in the synthesis of various pharmaceutical compounds. It is a polar aprotic solvent that is particularly useful in reactions involving strong nucleophiles, such as alkoxides and enolates.

One of the primary applications of DIPF is in peptide synthesis, where it is used as a base and as a solvent to facilitate the reaction between amino acids. DIPF is also commonly used in the synthesis of natural products, heterocycles, and other organic compounds.