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Lanthanum trifluoromethanesulfonate is primarily used as a Lewis acid catalyst in organic synthesis, particularly in the synthesis of various pharmaceuticals and agrochemicals. It is commonly used in reactions such as aldol condensations, Friedel-Crafts reactions, and cyclizations.

In pharmaceutical applications, lanthanum trifluoromethanesulfonate is used as a catalyst in the synthesis of various drugs, such as anti-cancer agents, antibiotics, and antiviral agents.