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L(-)-Pipecolinic acid cas 3105-95-1 Pharmaceutical Intermediate

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L(-)-Pipecolinic acid (or L-Pipecolic Acid) is a non-proteinogenic amino acid, a derivative of lysine, crucial in plant defense (systemic acquired resistance) and a marker for certain human peroxisomal disorders like Zellweger syndrome, where its accumulation indicates enzyme deficiency in lysine metabolism, acting as a signaling molecule and inhibitor of GABA binding in brains. It’s also used in research as a peptide synthesis reagent and analytical standard, known as L-homoproline. 

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CAS Number: 3105-95-1

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Description

1. Pharmaceutical Field (Core Applications)

a. Pharmaceutical Intermediates: Used in the synthesis of anti-HIV drugs, antidepressants, antibacterial agents, and more, serving as key building blocks for chiral drug molecules.

b. Drug Optimization Raw Materials: Utilized to modify drug molecules through their chiral structures, enhancing the bioactivity, selectivity, and metabolic safety of drugs.

c. Peptide Drug Synthesis: Acts as a component of polypeptide chains, employed in the preparation of peptide drugs with specific physiological functions (e.g., antimicrobial peptides, regulatory peptides).

2. Fine Chemical Industry

a. Chiral Catalyst Ligands: Can coordinate with metal ions to prepare chiral catalysts, used in asymmetric synthesis reactions (e.g., hydrogenation, cycloaddition reactions).

b. Organic Synthesis Intermediates: Applied in the synthesis of dyes, fragrances, food additives, etc., with their cyclic structures imparting special properties to the products.

3. Materials Science Field

a. Polymer Material Monomers: Used in the preparation of functional polymer materials (e.g., polyamides, polyurethanes), enhancing the mechanical strength and biocompatibility of the materials.

b. Biomaterial Modifiers: Employed to modify biomedical materials (e.g., artificial cartilage, tissue engineering scaffolds), improving their cell compa

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