Pharmint

磷光D

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Phospholipase D (PLD) is a crucial enzyme that hydrolyzes phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline, acting as a key regulator in signal transduction, membrane trafficking, cytoskeletal dynamics, and cell proliferation in organisms from bacteria to mammals. PA itself is a vital lipid second messenger, which can be further converted to other signaling molecules like diacylglycerol (DAG) and lysophosphatidic acid (LPA), influencing pathways like PKC, PI3K/Akt, and mTOR, and playing roles in development, cancer, and neurological disorders. 

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CAS Number: 9001-87-0

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由:

1. Biopharmaceuticals and Medical Field

a. Drug Development Tool: Used for studying cell signaling pathways (e.g., phosphatidylinositol signaling pathways), aiding in research on the pathogenesis of diseases such as tumors and inflammation.

b. Nucleic Acid Delivery Vehicle Preparation: Modifies the surface of liposomes through PLD-catalyzed transphosphatidylation reactions, enhancing the delivery efficiency and targeting of nucleic acid drugs (e.g., mRNA vaccines, siRNA).

c. Diagnostic Reagent Raw Material: Serves as a tool enzyme for in vitro diagnostics of phospholipid metabolism-related diseases, assisting in detecting liver function and cardiovascular disease markers.

2. Food Industry Field

a. Food Additive Production: Produces phosphatidylserine, catalyzes phospholipid modification, and manufactures food emulsifiers such as lysophospholipids and functional phospholipids to improve food texture, stability, and shelf life.

b. Oil Refining: Used to remove phospholipid impurities from oils (degumming), enhancing the purity and quality of edible oils and reducing the generation of harmful substances in subsequent processing.

c. Dairy Product Improvement: Added to dairy products to regulate milk fat structure, enhancing emulsification stability and nutritional value.

3. Cosmetics Field

a. Skincare Ingredient: Catalyzes the synthesis of ceramide precursors from phospholipids, helping repair the skin barrier and improve conditions of dryness and sensitivity, and is added to moisturizing creams and repair serums.

b. Hair Care Component: Modifies the lipid layer on the hair surface, enhancing smoothness and damage resistance, and is used in shampoo and conditioner formulations.

4. Biochemical Engineering Field

a. Biodiesel Production: Catalyzes the transesterification of vegetable oils or animal fats to efficiently synthesize biodiesel, reducing the stringency of reaction conditions (e.g., enabling reactions at low temperatures and pressures).

b. Functional Phospholipid Synthesis: Utilizes transphosphatidylation reactions to directionally synthesize high-value special phospholipids (e.g., phosphatidylserine, phosphatidylethanolamine) for use in health products and pharmaceutical excipients.

c. Biosensor Construction: Immobilized PLD serves as a biological recognition element to develop biosensors for detecting phospholipids and choline-based substances, applied in environmental monitoring and food testing.

Weight 25 kg
Dimensions 25 × 15 cm

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