Alkaline phosphatase in serum consists of four structural genotypes: the liverbone-kidney type, the intestinal type, the placental type and the variant from germ cells. It occurs in osteoblasts, hepatocytes, kidneys, spleen, placenta, prostate, leukocytes and the small intestine. The liverbone-kidney type is particularly important. A rise in the Alkaline Phosphatase activity occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget`s disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors. A considerable rise in the Alkaline Phosphatase activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth. Various reference values for the purposes of clinical evaluation have been assigned to differing age groups. In 1946, Bessey, Lowry and Brock published a method for the determination of Alkaline Phosphatase using p-nitrophenyl phosphate as substrate buffered with glycine\/NaOH. in 1967, Hausamen et al improved upon the method by using Diethanolamine as buffer. The “optimized standard method” assay described here meets the 1972 recommendations of the “Deutschen Gesellschaft für Klinische Chemie (German Society of Clinical Chemistry)<\/p>","protected":false},"excerpt":{"rendered":"
Intended Use:
\nLiquiMAX Alkaline Phosphatase kit for the quantitative determination of alkaline phosphatase (ALP) in human serum.<\/p>\n
Product Features
\n\u25cf Liquid Stable, Ready to use Two Reagents (4 parts R1+1 part R2)
\n\u25cf 2 Minutes increasing kinetic reaction (10 Sec Delay+120 Sec
\nMeasuring)
\n\u25cf PNPP Analogues are used.
\n\u25cf Measuring Wavelength 405 nm
\n\u25cf Kinetic factor 3104 at 37\u00b0 C.
\n\u25cf Linearity 1500 IU\/L
\n\u25cf Serum is the only specimen
\n\u25cf Available as multipurpose reagents and dedicated system packs<\/p>","protected":false},"featured_media":9901,"comment_status":"open","ping_status":"closed","template":"","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"product_cat":[112],"product_tag":[150,151],"class_list":{"0":"post-9908","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-others","7":"product_tag-alkaline-phosphatase","8":"product_tag-serum","9":"desktop-align-left","10":"tablet-align-left","11":"mobile-align-left","12":"ast-product-gallery-layout-vertical","13":"ast-magnify-disabled","14":"ast-product-tabs-layout-distributed","16":"first","17":"instock","18":"shipping-taxable","19":"purchasable","20":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/product\/9908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/comments?post=9908"}],"version-history":[{"count":0,"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/product\/9908\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/media\/9901"}],"wp:attachment":[{"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/media?parent=9908"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/product_cat?post=9908"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pharmint.net\/es\/wp-json\/wp\/v2\/product_tag?post=9908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}