Alkaline phosphatase in serum consists of four structural genotypes: the liver-bone-kidney type, the intestinal type, the placental type and the variant from germ cells. It occurs in osteoblasts, hepatocytes, kidneys, spleen, placenta, prostate, leukocytes and the small intestine. The liverbone-kidney type is particularly important. A rise in the Alkaline Phosphatase activity occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget`s disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors. A considerable rise in the Alkaline Phosphatase activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth. Various reference values for the purposes of clinical evaluation have been assigned to differing age groups. In 1946, Bessey, Lowry and Brock published a method for the determination of Alkaline Phosphatase using p-nitrophenyl phosphate as substrate buffered with glycine\/NaOH. This assay described here meets the IFCC recommendations and uses AMPbuffer.<\/p>","protected":false},"excerpt":{"rendered":"
Intended Use:
\nIn vitro test for the quantitative determination of alkaline phosphatase (ALP) in human serum.<\/p>\n
Product Features:
\n\u25cf Liquid Stable, Ready to use Mono Reagent
\n\u25cf Available as mono test vials
\n\u25cf PNPP Analogue used for better stability
\n\u25cf 2 Minutes increasing kinetic reaction (60Sec Delay+60 Sec
\nMeasuring)
\n\u25cf Measuring Wavelength 405 nm
\n\u25cf Kinetic factor 3750 at 37\u00b0 C.
\n\u25cf Linearity 1250 IU\/L
\n\u25cf Serum is the only specimen
\n\u25cf Available as multipurpose reagents and dedicated system packs<\/p>","protected":false},"featured_media":9902,"comment_status":"open","ping_status":"closed","template":"","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"product_cat":[112],"product_tag":[150,151],"class_list":{"0":"post-9906","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-others","7":"product_tag-alkaline-phosphatase","8":"product_tag-serum","9":"desktop-align-left","10":"tablet-align-left","11":"mobile-align-left","12":"ast-product-gallery-layout-vertical","13":"ast-magnify-disabled","14":"ast-product-tabs-layout-distributed","16":"first","17":"instock","18":"shipping-taxable","19":"purchasable","20":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product\/9906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/comments?post=9906"}],"version-history":[{"count":0,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product\/9906\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/media\/9902"}],"wp:attachment":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/media?parent=9906"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product_cat?post=9906"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product_tag?post=9906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}