{"id":8285,"date":"2022-09-12T21:19:03","date_gmt":"2022-09-12T13:19:03","guid":{"rendered":"https:\/\/pharmint.co\/?post_type=product&p=8285"},"modified":"2023-11-26T22:25:08","modified_gmt":"2023-11-26T16:55:08","slug":"akynzeo","status":"publish","type":"product","link":"https:\/\/pharmint.net\/ar\/product\/akynzeo\/","title":{"rendered":"AKYNZEO"},"content":{"rendered":"

AKYNZEO (300 mg netupitant\/0.5 mg palonosetron) capsules are an oral combination product of netupitant, a substance P\/neurokinin 1 (NK-1) receptor antagonist<\/a>, and palonosetron hydrochloride, a serotonin<\/a>-3 (5-HT3) receptor antagonist. Both netupitant and palonosetron hydrochloride are anti-nausea and anti-emetic<\/a> agents.<\/p>\n

Netupitant is chemically described: 2-[3,5-bis(trifluoromethyl)phenyl]-N, 2 dimethyl-N-[4-(2methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl] propanamide. The empirical formula is C30<\/span>H32<\/span>F6<\/span>N4<\/span>O, with a molecular weight of 578.61. Netupitant exists as a single isomer and has the following structural formula:<\/p>\n

\n<\/p>\n\n\n
\"Netupitant<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n<\/p>

Palonosetron hydrochloride is chemically described: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride. The empirical formula is C19<\/span>H24<\/span>N2<\/span>O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following structural formula:<\/p>\n

\n<\/p>\n\n\n
\"Palonosetron<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n<\/p>

Netupitant is white to off-white crystalline powder. It is freely soluble in toluene and acetone, soluble in isopropanol and ethanol, and very slightly soluble in water.<\/p>\n

Palonosetron hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.<\/p>\n

Each AKYNZEO capsule is composed of one white-caramel hard gelatin capsule which contains three tablets each containing 100 mg netupitant and one gelatin capsule containing 0.5 mg palonosetron (equivalent to 0.56 mg palonosetron hydrochloride). The inactive ingredients are butylated hydroxyanisole (BHA), croscarmellose sodium, gelatin, glycerin, magnesium stearate, microcrystalline cellulose, mono-and di-glycerides of capryl\/capric acid, polyglyceryl dioleate, povidone K-30, purified water, red iron oxide, silicon dioxide, sodium stearyl fumarate, sorbitol, sucrose fatty acid esters, titanium dioxide and yellow iron oxide. It may contain traces of medium-chain triglycerides, lecithin, and denatured ethanol.<\/p>\n

AKYNZEO (235 mg fosnetupitant\/0.25 mg palonosetron) for injection is a combination product of fosnetupitant, a prodrug of netupitant, which is a substance P\/neurokinin 1 (NK-1) receptor antagonist, and palonosetron hydrochloride, a serotonin-3 (5-HT3) receptor antagonist.<\/p>","protected":false},"excerpt":{"rendered":"

Akynzeo (netupitant and palonosetron) is a combination of anti-nausea and\u00a0anti-emetic<\/a>\u00a0drugs used for the prevention of acute and delayed\u00a0nausea and vomiting<\/a>\u00a0associated with initial and repeat courses of cancer\u00a0chemotherapy<\/a>, including, but not limited to, highly emetogenic chemotherapy.<\/p>\n

What are side effects of Akynzeo?<\/h4>\n

Common side effects of Akynzeo include:<\/p>\n