{"id":54828,"date":"2023-02-27T18:05:35","date_gmt":"2023-02-27T12:35:35","guid":{"rendered":"https:\/\/pharmint.co\/?post_type=product&#038;p=54828"},"modified":"2023-11-27T00:16:33","modified_gmt":"2023-11-26T18:46:33","slug":"akynzeo-2","status":"publish","type":"product","link":"https:\/\/pharmint.net\/ar\/product\/akynzeo-2\/","title":{"rendered":"AKYNZEO"},"content":{"rendered":"<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\"><span style=\"color: #000000;font-family: Open Sans, sans-serif\">AKYNZEO (300 mg netupitant\/0.5 mg palonosetron) capsules are an oral combination product of netupitant, a substance P\/neurokinin 1 (NK-1) receptor antagonist, and palonosetron hydrochloride, a serotonin-3 (5-HT3) receptor antagonist. Both netupitant and palonosetron hydrochloride are anti-nausea and anti-emetic agents.<\/span><\/p>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">Netupitant is chemically described: 2-[3,5-bis(trifluoromethyl)phenyl]-N, 2 dimethyl-N-[4-(2methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl] propanamide. The empirical formula is C<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">30<\/span>H<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">32<\/span>F<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">6<\/span>N<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">4<\/span>O, with a molecular weight of 578.61. Netupitant exists as a single isomer and has the following structural formula:<\/p>\n<table class=\"blackpic\" style=\"width: 906.172px;margin-bottom: 10px;border-spacing: 0px\" width=\"322\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td><img fetchpriority=\"high\" decoding=\"async\" style=\"border-style: none;width: auto\" title=\"Netupitant - Structural Formula - Illustration\" src=\"https:\/\/images.rxlist.com\/images\/rxlist\/akynzeo1.gif\" alt=\"Netupitant - Structural Formula - Illustration\" width=\"322\" height=\"185\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">Palonosetron hydrochloride is chemically described: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride. The empirical formula is C<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">19<\/span>H<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">24<\/span>N<span style=\"font-size: 12px;line-height: 0;vertical-align: baseline\">2<\/span>O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following structural formula:<\/p>\n<table class=\"blackpic\" style=\"width: 906.172px;margin-bottom: 10px;border-spacing: 0px\" width=\"210\" cellspacing=\"0\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" style=\"border-style: none;width: auto\" title=\"Palonosetron hydrochloride - Structural Formula - Illustration\" src=\"https:\/\/images.rxlist.com\/images\/rxlist\/akynzeo2.gif\" alt=\"Palonosetron hydrochloride - Structural Formula - Illustration\" width=\"210\" height=\"195\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">Netupitant is white to off-white crystalline powder. It is freely soluble in toluene and acetone, soluble in isopropanol and ethanol, and very slightly soluble in water.<\/p>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">Palonosetron hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.<\/p>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">Each AKYNZEO capsule is composed of one white-caramel hard gelatin capsule which contains three tablets each containing 100 mg netupitant and one gelatin capsule containing 0.5 mg palonosetron (equivalent to 0.56 mg palonosetron hydrochloride). The inactive ingredients are butylated hydroxyanisole (BHA), croscarmellose sodium, gelatin, glycerin, magnesium stearate, microcrystalline cellulose, mono-and di-glycerides of capryl\/capric acid, polyglyceryl dioleate, povidone K-30, purified water, red iron oxide, silicon dioxide, sodium stearyl fumarate, sorbitol, sucrose fatty acid esters, titanium dioxide and yellow iron oxide. It may contain traces of medium-chain triglycerides, lecithin, and denatured ethanol.<\/p>\n<p style=\"line-height: 28px;margin: 15px 0px;color: #000000;font-family: 'Open Sans', sans-serif\">AKYNZEO (235 mg fosnetupitant\/0.25 mg palonosetron) for injection is a combination product of fosnetupitant, a prodrug of netupitant, which is a substance P\/neurokinin 1 (NK-1) receptor antagonist, and palonosetron hydrochloride, a serotonin-3 (5-HT3) receptor antagonist.<\/p>","protected":false},"excerpt":{"rendered":"<p>Akynzeo (netupitant and palonosetron) is a combination of anti-nausea and anti-emetic drugs used for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy.<\/p>\n<p>What are side effects of Akynzeo?<\/p>\n<p>Common side effects of Akynzeo include: headache, weakness, indigestion, fatigue, constipation, and skin redness.<\/p>","protected":false},"featured_media":13720,"comment_status":"closed","ping_status":"closed","template":"","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ep_exclude_from_search":false},"product_cat":[323,322],"product_tag":[399],"class_list":{"0":"post-54828","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medicines","7":"product_cat-tb-tumor-cancer-drugs","8":"product_tag-anti-cancer-medication","9":"desktop-align-left","10":"tablet-align-left","11":"mobile-align-left","12":"ast-product-gallery-layout-vertical","13":"ast-product-gallery-with-no-image","14":"ast-magnify-disabled","15":"ast-product-tabs-layout-distributed","17":"first","18":"instock","19":"shipping-taxable","20":"purchasable","21":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product\/54828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/comments?post=54828"}],"version-history":[{"count":0,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product\/54828\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/media\/13720"}],"wp:attachment":[{"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/media?parent=54828"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product_cat?post=54828"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pharmint.net\/ar\/wp-json\/wp\/v2\/product_tag?post=54828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}